Prävention

Curcumin weist ein breites Spektrum an Wirkungen auf und zeigt vielversprechende Eigenschaften für die Prävention und mögliche Behandlung verschiedener Erkrankungen wie beispielsweise Tumorerkrankungen, Allergien, Autoimmunerkrankungen, Herz-Kreislauf-Erkrankungen, Diabetes mellitus, Arthrose, Reizdarmsyndrom (RDS) und chronisch entzündliche Darmerkrankungen (CED) [1-6]. Die molekularen Wirkmechanismen von Curcumin sind mittlerweile gut erforscht. Viele seiner gesundheitlichen Effekte lassen sich auf die Stärkung des antioxidativen Systems, die Entzündungshemmung und/oder die Modulation des Immunsystems zurückführen.

Curcumin in der Prävention von:

• Alzheimer-Demenz [7]
• Diabetes mellitus Typ 2 [8, 9]
• Entzündlichen Erkrankungen [10]
• Metabolischem Syndrom [11]
• Migräne [12]
• Myalgie (Muskelschmerzen) [13-15]

Literatur

1. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol. 2009;41:40-59.
2. Greg M et al. Neuroprotective effects of curcumin. Adv Exp Med Biol. 2007;595:197-212.
3. Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. 2012;26(11):1719-25.
4. Ali T, Shakir F, Morton J. Curcumin and inflammatory bowel disease: biological mechanisms and clinical implication. Digestion 2012;85:249-255.
5. Shanmugam MK, Rane G, Kanchi MM, Arfuso F, Chinnathambi A, Zayed ME, Alharbi SA, Tan BK, Kumar AP, Sethi G. The multifaceted role of curcumin in cancer prevention and treatment. Molecules 2015;20:2728-2769.
6. DiSilvestro RA, Joseph E, Zhao S, Bomser J. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutrition J. 2012;11:79.
7. Voulgaropoulou SD, van Amelsvoort TAMJ, Prickaerts J, Vingerhoets C. The effect of curcumin on cognition in Alzheimer's disease and healthy aging: A systematic review of pre-clinical and clinical studies. Brain Res. 2019 Dec 15;1725:146476.
8. Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012 Nov;35(11):2121-7.
9. Thota RN, Rosato JI, Dias CB, Burrows TL, Martins RN, Garg ML. Dietary Supplementation with Curcumin Reduce Circulating Levels of Glycogen Synthase Kinase-3β and Islet Amyloid Polypeptide in Adults with High Risk of Type 2 Diabetes and Alzheimer's Disease. Nutrients. 2020 Apr 9;12(4):1032.
10. Gorabi AM, Abbasifard M, Imani D, Aslani S, Razi B, Alizadeh S, Bagheri-Hosseinabadi Z, Sathyapalan T, Sahebkar A. Effect of curcumin on C-reactive protein as a biomarker of systemic inflammation: An updated meta-analysis of randomized controlled trials. Phytother Res. 2022 Jan;36(1):85-97.
11. Cicero AFG, Sahebkar A, Fogacci F, Bove M, Giovannini M, Borghi C. Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial. Eur J Nutr. 2020 Mar;59(2):477-483.
12. Abdolahi M, Karimi E, Sarraf P, Tafakhori A, Siri G, Salehinia F, Sedighiyan M, Asanjarani B, Badeli M, Abdollahi H, Yoosefi N, Yousefi A, Rad AS, Djalali M. The omega-3 and Nano-curcumin effects on vascular cell adhesion molecule (VCAM) in episodic migraine patients: a randomized clinical trial. BMC Res Notes. 2021 Jul 23;14(1):283.
13. Dias KA, da Conceição AR, Oliveira LA, Pereira SMS, Paes SDS, Monte LF, Sarandy MM, Novaes RD, Gonçalves RV, Della Lucia CM. Effects of Curcumin Supplementation on Inflammatory Markers, Muscle Damage, and Sports Performance during Acute Physical Exercise in Sedentary Individuals. Oxid Med Cell Longev. 2021 Oct 7;2021:9264639.
14. Fernández-Lázaro D, Mielgo-Ayuso J, Seco Calvo J, Córdova Martínez A, Caballero García A, Fernandez-Lazaro CI. Modulation of Exercise-Induced Muscle Damage, Inflammation, and Oxidative Markers by Curcumin Supplementation in a Physically Active Population: A Systematic Review. Nutrients. 2020 Feb 15;12(2):501.
15. Fang W, Nasir Y. The effect of curcumin supplementation on recovery following exercise-induced muscle damage and delayed-onset muscle soreness: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2021 Apr;35(4):1768-1781.