Krankheiten/Gesundheitsrisiken, für die eine Prävention mit Quercetin indiziert sind – Prävention

Quercetin ist eines der wichtigsten und am besten erforschten Bioflavonoide mit antioxidativen, antiinflammatorischen (antientzündlichen), antiproliferativen, antikanzerogenen (krebshemmenden), antidiabetischen und antiviralen Eigenschaften. Daher gilt der Phytonährstoff als vielversprechend für den präventiven Einsatz bei einer Vielzahl von verschiedenen Erkrankungen, darunter Hypertonie (Bluthochdruck), Atherosklerose (Arteriosklerose/Arterienverkalkung), Infektionskrankheiten, Diabetes mellitus und Diabeteskomplikationen, Asthma bronchiale, Polyzystisches-Ovar-Syndrom (PCO-Syndrom), Tumorerkrankungen, chronisch entzündliche Darmerkrankungen (CED) und Morbus Alzheimer [1-4].

Quercetin in der Prävention von:

• Asthma bronchiale [5]
• Hypertonie (Bluthochdruck) [6-8]
• Chronisch Ischämische Herzkrankheit [9]
• Entzündliche Erkrankungen [10, 11]
• Kognitiver Störung [12]
• Kolorektales Karzinom (Darmkrebs) [13]
• Rauchen-assoziierte Tumorerkrankungen [14]

Literatur

1. Batiha GE, Beshbishy AM, Ikram M, Mulla ZS, El-Hack MEA, Taha AE, Algammal AM, Elewa YHA. The pharmacological activity, biochemical properties, and pharmacokinetics of the major natural polyphenolic flavonoid: quercetin. Foods. 2020;23;9(3):374.
2. Ulusoy HG, Sanlier N. A minireview of quercetin: from its metabolism to possible mechanisms of its biological activities. Crit Rev Food Sci Nutr. 2020;60(19):3290-3303.
3. Anand David AV, Arulmoli R, Parasuraman S. Overviews of biological importance of quercetin: a bioactive flavonoid. Pharmacogn Rev. 2016;10(20):84-89.
4. Russo M, Spagnuolo C, Tedesco I, Bilotto S, Russo GL. The flavonoid quercetin in disease prevention and therapy: facts and fancies. Biochem Pharmacol. 2012;83(1):6-15.
5. Cesarone MR, Belcaro G, Hu S, Dugall M, Hosoi M, Ledda A, Feragalli B, Maione C, Cotellese R. Supplementary prevention and management of asthma with quercetin phytosome: a pilot registry. Minerva Med. 2019;110(6):524-529.
6. Popiolek-Kalisz J, Fornal E. The Effects of Quercetin Supplementation on Blood Pressure – Meta-Analysis. Curr Probl Cardiol. 2022 Nov;47(11):101350.
7. Serban MC, Sahebkar A, Zanchetti A, Mikhailidis DP, Howard G, Antal D, Andrica F, Ahmed A, Aronow WS, Muntner P, Lip GY, Graham I, Wong N, Rysz J, Banach M; Lipid and Blood Pressure Meta‐analysis Collaboration (LBPMC) Group. Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2016 Jul 12;5(7):e002713.
8. Brüll V, Burak C, Stoffel-Wagner B, Wolffram S, Nickenig G, Müller C, Langguth P, Alteheld B, Fimmers R, Naaf S, Zimmermann BF, Stehle P, Egert S. Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-)hypertension: a randomised double-blinded placebo-controlled cross-over trial. Br J Nutr. 2015 Oct 28;114(8):1263-77.
9. Arai Y, Watanabe S, Kimira M, Shimoi K, Mochizuki R, Kinae N. Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr. 2000 Sep;130(9):2243-50.
10. Mohammadi-Sartang M, Mazloom Z, Sherafatmanesh S, Ghorbani M, Firoozi D. Effects of supplementation with quercetin on plasma C-reactive protein concentrations: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2017 Sep;71(9):1033-1039.
11. Ou Q, Zheng Z, Zhao Y, Lin W. Impact of quercetin on systemic levels of inflammation: a meta-analysis of randomised controlled human trials. Int J Food Sci Nutr. 2020 Mar;71(2):152-163.
12. Nakamura Y, Watanabe H, Tanaka A, Nishihira J, Murayama N. Effect of quercetin glycosides on cognitive functions and cerebral blood flow: a randomized, double-blind, and placebo-controlled study. Eur Rev Med Pharmacol Sci. 2022 Dec;26(23):8700-8712.
13. Chang H, Lei L, Zhou Y, Ye F, Zhao G. Dietary Flavonoids and the Risk of Colorectal Cancer: An Updated Meta-Analysis of Epidemiological Studies. Nutrients. 2018 Jul 23;10(7):950.
14. Woo HD, Kim J. Dietary flavonoid intake and smoking-related cancer risk: a meta-analysis. PLoS One. 2013 Sep 19;8(9):e75604.